The Karoo Highlands Route is situated in the north-eastern part of the Western Cape and southern part of the Northern Cape in South Africa. The route includes the small Karoo towns of Matjiesfontein, Sutherland, Fraserburg, Williston, Carnarvon, Loxton, Victoria West and Beaufort West and is also commonly referred to as the Great Karoo. Sheep farming is the economic backbone of the Karoo and Karoo lamb has become the flagship export of the region.
The Karoo is known for its extreme climate. Daily temperatures average around 30°C in summer while winters often see snowfall in the high-lying areas such as Sutherland.